Monika Sachdeva1 
,
Murli Dhar Kharya2,
Ahmed Aljarbou3,
Taruna Katyal4
For correspondence:- Monika Sachdeva Email: monikasachdeva@rediffmail.com Tel:0096663802446
Received: 13 January 2011 Accepted: 24 November, 2011 Published: 25 December 2011
Citation: Sachdeva M, Kharya MD, Aljarbou A, Katyal T. Photoprotective Effects of Hydroalcohol Tagetes Erectus Extract Against UV-Induced Oxidative Damage in Mice. Trop J Pharm Res 2011; 10(6):747-753 doi: 10.4314/tjpr.v10i6.7
© 2011 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effects of topical application of Tagetes erectus hydroalcohol extract as a dermal antioxidant agent and evaluate its capacity to prevent ultraviolet (UV) –induced oxidative damage.
Methods: The plant flower was extracted with aqueous ethanol (60 %). Female Lacca mice were divided into five groups of 24 animals each. Group I was un-irradiated control (neither UV exposure nor any treatment received). Group II was irradiated control and received 5 min UV exposure twice a day. Groups III, 1V and V received both UV exposure and treatment of different concentrations of the extract, 4 h. prior to UV exposure. The degree of protection was quantified using biochemical tests (lipid peroxidation and glutathione level) and histopathological assessment.
Results: The results showed that 2% topical extract treatment reduced the effect of UV light-induced photoaging on mice skin by decreasing malondialdehyde (MDA) level by up to 50 % and increasing glutathione (GSH) level 3-fold (p < 0.01) compared to UV-irradiated control group. Histopathological evaluation also indicated a photo-protective effect on the extract-treated mice skin as no signs of histological changes were seen after UV exposure.
Conclusion: Topical application of T .erectus has a potential for preventing oxidative damage by UV irradiation.
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